Effects of Bariatric Surgery on Blood Sugar Levels
The Effects of Bariatric Surgeries on Glucose Metabolism
Recruiting
Early Phase 1Interventional Study
Post Bariatric SurgeryGastric BypassSleeve GastrectomyHypoglycemia After Gastric Bypass
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
18 – 65
Sex
Any
Trial phase
Early Phase 1
Study type
Interventional
Purpose
Other
Participants needed
200 (estimated)
Sponsor
The University of Texas Health Science Center at San Antonio · Other
Who this trial is looking for
This trial is looking for people who have had gastric bypass or sleeve gastrectomy surgery and healthy individuals without diabetes. Participants will help researchers understand how these surgeries affect blood sugar after eating.
Are You a Good Fit for This Trial?
You may be able to join if
I have low blood sugar levels below 50 mg/dl after RYGB surgery.
I have had bariatric surgery but do not have any symptoms.
I am healthy and have no personal history of diabetes.
I can physically visit the Cedars-Sinai Medical Center.
You may not be able to join if
I have active heart, lung, liver, gastrointestinal, or kidney disease.
I am pregnant.
I have uncontrolled high blood pressure or high cholesterol.
I have significant anemia with hemoglobin less than 11g/dL.
I am a prisoner or institutionalized.
I have type 2 diabetes.
I have serious medical or psychiatric issues during the study.
I have gastric outlet obstruction or severe diarrhea after RYGB.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer a few quick questions to see if you may meet the eligibility requirements.
The purpose of this study is learn the effect of gastric bypass surgery and sleeve gastrectomy on glucose metabolism mediated by neural and hormonal factors initiated after eating.
Trial Locations
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Status
Eligibility Criteria
Inclusion Criteria:
* Hypoglycemic RYGB patients with documented blood glucose level \<50 mg/dl
* Asymptomatic individuals with bariatric surgery
* Healthy non-surgical patients with no personal history of diabetes
* Subjects must physically be able to come to our clinical research center Cedars-Si…
Inclusion Criteria:
* Hypoglycemic RYGB patients with documented blood glucose level \<50 mg/dl
* Asymptomatic individuals with bariatric surgery
* Healthy non-surgical patients with no personal history of diabetes
* Subjects must physically be able to come to our clinical research center Cedars-Sinai Medical Center
Exclusion Criteria:
* Active heart, lung, liver, gastrointestinal or kidney disease; unable to give informed consent; pregnancy; uncontrolled high blood pressure or high cholesterol; significant anemia (hemoglobin \<11g/dL); prisoners or institutionalized individuals; type 2 diabetes mellitis; development of any serious medical or psychiatric illness during recruitment or studies;
* RYGB patients will be disqualified if they have gastric outlet obstruction or severe diarrhea.
* Healthy non-surgical patients with personal history of diabetes
For administration of atropine, the following exclusions also apply:
* History of glaucoma
* Uncontrolled hypertension (any subjects with BP\>140/90 and history of dyslipidemia
* Taking any medication that might interact with atropine and cannot be stopped will be excluded from the study)
* Myasthenia gravis
* Brain pathology
* Enlarged prostate in men
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