No Study Drug
Researchers observe your health over time — no experimental treatment is given.
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At a Glance
Age
18 and older
Sex
Any
Study type
Observational
Participants needed
7,000 (estimated)
Sponsor
University of Pittsburgh · Other
Who this trial is looking for
This trial is looking for people with esophageal disorders to help identify risk factors for developing esophageal cancer. Participants will provide medical history, blood, and tissue samples.
Are You a Good Fit for This Trial?
You may be able to join if
I have been diagnosed with an esophageal or gastroesophageal junction cancer
I have Barrett's metaplasia
I am being treated for gastroesophageal reflux disease (GERD)
I have achalasia
I have a hiatal hernia
You may not be able to join if
I have elevated pre-operative bloodwork
My platelet count is less than 150,000
My partial thromboplastin time (PTT) is 50 or above
My International Normalized Ratio (INR) is 1.8 or above
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer a few quick questions to see if you may meet the eligibility requirements.
The purpose of this study is to identify markers in the blood and tissue that could indicate risk factors for the development and progression of esophagus cancer. This research aims to collect medical history, blood, and tissue samples from patients who present with an esophageal disorder. Identifying genetic and behavioral risk factors involved in the development of esophageal cancer might allow …
The purpose of this study is to identify markers in the blood and tissue that could indicate risk factors for the development and progression of esophagus cancer. This research aims to collect medical history, blood, and tissue samples from patients who present with an esophageal disorder. Identifying genetic and behavioral risk factors involved in the development of esophageal cancer might allow for early detection and prevention. Survival and an opportunity for a cure with esophageal cancer will depend greatly on the stage of diagnosis. Tumors can develop changes in their genetic (hereditary) make-up, and these changes can sometimes be seen in normal tissues before the development of cancer. These genetic (hereditary) changes can serve as tumor markers and can be detected using methods that study changes in genetic material like DNA and RNA. The analysis of proteins can provide additional information. By identifying changes in these molecules that are different or altered in cancer, the investigators can use methods and tests for the detection of these changes.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Known or suspected esophageal or gastroesophageal junction malignancy
* Known Barrett's metaplasia
* Clinical management of symptomatic gastroesophageal reflux disease (GERD)
* Achalasia
* Hiatal hernia
Exclusion Criteria:
* Elevated pre-operative bloodwork will not have the…
Inclusion Criteria:
* Known or suspected esophageal or gastroesophageal junction malignancy
* Known Barrett's metaplasia
* Clinical management of symptomatic gastroesophageal reflux disease (GERD)
* Achalasia
* Hiatal hernia
Exclusion Criteria:
* Elevated pre-operative bloodwork will not have the additional biopsies taken.
* Platelet count less than 150,000, partial thromboplastin time (PTT) of 50 or above, and/or International Normalized Ratio (INR) of 1.8 or above will not have the additional biopsies taken.
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