Psychophysical Studies of Cancer Therapy Pain

Inclusion Criteria: 1. Since moderate pain, albeit brief, will be induced, this feasibility project will be limited to consenting adults, 18 years old or older, in which there is also a well established QST database. 2. The subjects must be able to understand the nature of the study and have signed consent. 3. The patients must either: a) have pain that has developed as a consequence of cancer therapy with either vinca alkaloids, taxanes, bortezomib, thalidomide, platinum-based compounds or ionizing irradiation. OR b) have no pain that has developed as a consequence of cancer therapy, and are just entering chemotherapy with taxanes, vinka alkaloids, bortezomib, thalidomide, or platinum-based compounds 4. (For Healthy Controls) Willing to participate and have signed an informed consent. Exclusion Criteria: 1. Patients who refuse to participate or who are determined incapable of completing the research. 2. (For Healthy Controls) Receiving anti-coagulants, immunosuppressed or diabetic.