TRANSCRIBE (Transcriptomic Analysis of Left Ventricular Gene Expression)
Recruiting
Observational Study
Cardiovascular Diseases
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
At a Glance
- Age
- 20 and older
- Sex
- Any
- Study type
- Observational
- Participants needed
- 350 (estimated)
- Sponsor
- Brigham and Women's Hospital · Other
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About This Trial
Hypothesis: The investigators hypothesize that genetic variants will alter gene expression in response to ischemia during cardiopulmonary bypass. To test this, the investigators will be taking small pieces of heart tissue from patients undergoing heart surgery before and after this period of ischemia. This will be compared to blood gene expression in blood cells and analyzed with the patients' gen…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Aged greater than 20 years
* Undergoing aortic valve surgery with or without CABG surgery
* Receive and apical vent as part of the surgery
Exclusion Criteria:
* Will not receive an apical left ventricular vent
Contacts