Mechanism(s) of Airflow Limitation During Exacerbation of Asthma
Recruiting
Phase 4Interventional Study
Asthma
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Prior Safety Data
This treatment has already been tested in at least one earlier human trial.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
10 – 80
Sex
Any
Trial phase
Phase 4
Study type
Interventional
Purpose
Basic Science
Participants needed
50 (estimated)
Sponsor
Gelb, Arthur F., M.D. · Individual
Who this trial is looking for
This trial is looking for people with asthma who are stable and being treated. Participants will use inhaled medications while the researchers study their breathing and lung function.
Are You a Good Fit for This Trial?
Must be takingInhaled corticosteroidsLong acting beta2-agonists
You may be able to join if
I am a non-smoker with a smoking history of less than 10 pack years.
I am between 10 and 80 years old.
I have moderate to severe asthma.
I am currently being treated for asthma.
I have FEV1/FVC less than 70% after taking 180ug albuterol.
You may not be able to join if
I am pregnant.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer a few quick questions to see if you may meet the eligibility requirements.
The purpose of this study is to evaluate the site and mechanisms responsible for expiratory airflow limitation in chronic, treated, non-smoking, stable asthmatics with moderate to severe persistent expiratory airflow obstruction. Treatment will include inhaled corticosteroids and long acting beta2agonists. The investigators are interested in determining whether the large and/or small airways are t…
The purpose of this study is to evaluate the site and mechanisms responsible for expiratory airflow limitation in chronic, treated, non-smoking, stable asthmatics with moderate to severe persistent expiratory airflow obstruction. Treatment will include inhaled corticosteroids and long acting beta2agonists. The investigators are interested in determining whether the large and/or small airways are the predominant site of airflow limitation. The investigators are also interested in determining whether intrinsic small airways obstruction and/or loss of lung elastic recoil is responsible for expiratory airflow limitation. The investigators are also interested to evaluate the role of varying doses of inhaled corticosteroids to suppress large and small airway inflammation using exhaled nitric oxide as surrogate markers of inflammation. For comparison purposes, spirometry and measurements of exhaled nitric oxide will also be obtained if possible during a naturally occurring exacerbation of asthma.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Current non-smoking (\<10 pack yr smoking history)
* Stable, treated asthmatics
* Age 10-80 yr
* post 180ug albuterol by MDI: FEV 1/FVC \< 70% and FEV 1 \<80% predicted
Exclusion Criteria:
* Pregnancy
Inclusion Criteria:
* Current non-smoking (\<10 pack yr smoking history)
* Stable, treated asthmatics
* Age 10-80 yr
* post 180ug albuterol by MDI: FEV 1/FVC \< 70% and FEV 1 \<80% predicted
Exclusion Criteria:
* Pregnancy
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