MRI and MRS Techniques for Brain and Muscle Imaging
Development of Magnetic Resonance Spectroscopic Imaging Techniques for Imaging Metabolites in Human Brain and Muscle
Recruiting
N/AInterventional Study
Brain MappingHealthy Volunteer
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
18 – 65
Sex
Any
Study type
Interventional
Purpose
Basic Science
Participants needed
300 (estimated)
Sponsor
National Institute of Mental Health (NIMH) · NIH
Who this trial is looking for
This trial is looking for healthy volunteers aged 18 to 65 to help researchers improve imaging techniques for studying brain and muscle chemistry. Participants will undergo a health screening and then have MRI and MRS scans to gather data on brain activity.
Are You a Good Fit for This Trial?
Rules you outMultiple sclerosisParkinson's diseaseSeizure disorderTraumatic brain injury
You may be able to join if
I am between 18 and 65 years old.
I can give written informed consent.
I am healthy based on my medical history and physical exam.
I am enrolled in Protocol 01-M-0254 or Protocol 17-M-0181.
You may not be able to join if
I have a current Axis 1 diagnosis.
I have significant laboratory abnormalities.
I have a positive HIV test.
I have metallic objects in my body that could be affected by MRI.
I have a fear of enclosed spaces that prevents me from undergoing an MRI.
I have a history of neurological illness or injury.
I cannot lie flat on the scanning bed for about two and a half hours.
I am pregnant or breastfeeding.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer a few quick questions to see if you may meet the eligibility requirements.
Background:
\- Magnetic resonance imaging (MRI) is a widely used scanning technique to obtain images of the human body and evaluate activity in the brain. A particular MRI method called magnetic resonance spectroscopy (MRS) can be used to study brain chemistry as well, which may help researchers who are studying new treatments for psychiatric illnesses. Researchers are interested in improving cur…
Background:
\- Magnetic resonance imaging (MRI) is a widely used scanning technique to obtain images of the human body and evaluate activity in the brain. A particular MRI method called magnetic resonance spectroscopy (MRS) can be used to study brain chemistry as well, which may help researchers who are studying new treatments for psychiatric illnesses. Researchers are interested in improving current MRI and MRS techniques, as well as developing new MRI and MRS techniques to view and measure brain chemicals and brain activity.
Objectives:
\- To implement, develop, and optimize brain chemistry imaging techniques using magnetic resonance imaging and magnetic resonance spectroscopy.
Eligibility:
\- Healthy individuals between 18 and 65 years of age.
Design:
* This study will involve a screening visit and a scanning visit at the National Institutes of Health Clinical Center.
* Participants will be screened with a full medical and physical examination, blood and urine tests, and neurological testing.
* During the second visit, participants will have an MRI scan of the brain. (Participants who have received an MRI within the past year will not need to have a second one; the images of the previous scan will be used for this study.) All participants will then have an MRS scan using the same scanning equipment.
Trial Locations
Loading…
Loading trial locations…
Facility
City
State
Country
Status
Eligibility Criteria
* INCLUSION CRITERIA:
* 18-65 years of age
* able to give written informed consent
* healthy based on medical history and physical exam
* enrolled in Protocol 01-M-0254 or Protocol 17-M-0181
EXCLUSION CRITERIA:
* Any current Axis 1 diagnosis
* Clinically significant laboratory abnormalities
* Posi…
* INCLUSION CRITERIA:
* 18-65 years of age
* able to give written informed consent
* healthy based on medical history and physical exam
* enrolled in Protocol 01-M-0254 or Protocol 17-M-0181
EXCLUSION CRITERIA:
* Any current Axis 1 diagnosis
* Clinically significant laboratory abnormalities
* Positive HIV test
* Metallic foreign bodies that would be affected by the magnetic resonance imaging (MRI) magnet, or fear of enclosed spaces likely to make the subject unable to undergo an MRI scan.
* History of neurological illness or injury with the potential to affect study data interpretation, such as multiple sclerosis, Parkinson s disease, seizure disorder or traumatic brain injury
* Inability to lie flat on camera bed for about two and a half hours
* Pregnant or breastfeeding
* Current substance use disorder based on DSM-5
* NIMH employees and staff and their immediate family members will be excluded from the study per NIMH policy.
Picking one helps us show the most relevant trials first.
Your results are loading in the background — you can
change this any time from the results page.
Set your location to continue
Find My Trials uses your location to surface clinical trials near you.
Add your city or zip code to your profile and try again.