No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
Up to 90
Sex
Any
Study type
Observational
Participants needed
1,899 (estimated)
Sponsor
Vanderbilt University Medical Center · Other
Who this trial is looking for
This trial is looking for people with certain types of pulmonary hypertension, including those with family members affected by it. Participants will undergo tests and provide blood samples to help understand the disease better.
Are You a Good Fit for This Trial?
You may be able to join if
I have been diagnosed with idiopathic pulmonary arterial hypertension
I have been diagnosed with heritable pulmonary arterial hypertension
I have been diagnosed with associated pulmonary arterial hypertension
I am a family member of someone with this condition
I am aged between 0 and 90
I can easily get to the clinic for testing
I can tolerate fasting before my tests
You may not be able to join if
I have another diagnosis
I am older than 90
I am younger than 12 for skin biopsy
I have difficulty reaching the clinic for testing
I cannot tolerate fasting before my tests
I am younger than 7 for some parts of the study
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
Our hypothesis is that optimal treatment of the dysfunctional metabolic pathways which underlie PAH will improve pulmonary vascular function and consequences of the disease.
Trial Locations
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Facility
City
State
Country
Status
Eligibility Criteria
Inclusion Criteria:
Project 1
Inclusion:
1. Diagnosis of IPAH (idiopathic pulmonary arterial hypertension), HPAH (heritable pulmonary arterial hypertension), or APAH (associated pulmonary arterial hypertension), family members of affected persons
2. Age 0-90, age 12-90 for skin biopsy
Exclusion:…
Inclusion Criteria:
Project 1
Inclusion:
1. Diagnosis of IPAH (idiopathic pulmonary arterial hypertension), HPAH (heritable pulmonary arterial hypertension), or APAH (associated pulmonary arterial hypertension), family members of affected persons
2. Age 0-90, age 12-90 for skin biopsy
Exclusion:
1. Other diagnosis
2. Age greater than 90, age less than 12 or greater than 90 for skin biopsy
Project 2
Inclusion:
1. Diagnosis of IPAH, HPAH, or APAH, family members of affected persons
2. 0-90
3. Subjects with reasonably easy access to clinic for blood collection and other testing
4. Subject able to tolerate fasting state prior to sample collection and EndoPAT (endothelial function assessment) testing
Exclusion:
1. Other diagnosis
2. 0-90
3. Subjects with difficulty reaching clinic for blood collection and other testing
4. Subjects unable to tolerate fasting state
Project 3
Inclusion:
1. Diagnosis of IPAH, HPAH, or APAH, family members of affected persons
2. 7-90
Exclusion:
1. Other diagnosis
2. Age less than 7 or greater than 90
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Exclusion Criteria:
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