68Ga-DOTATATE PET/CT Imaging for Ectopic Cushing Syndrome

Prospective Evaluation of 68Ga-DOTATATE PET/CT, Octreotide and F-DOPA PET Imaging in Ectopic Cushing Syndrome

Recruiting Phase 2 Interventional Study
ACTH Cushing's Syndrome
No Placebo Group Every participant receives an active treatment — no one gets a placebo. Prior Safety Data This treatment has already been tested in at least one earlier human trial.
Ready to participate?

Review the details below, then apply to join this clinical trial.

At a Glance
Age
18 – 80
Sex
Any
Trial phase
Phase 2
Study type
Interventional
Purpose
Diagnostic
Participants needed
80 (estimated)
Sponsor
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) · NIH
Who this trial is looking for

This trial is looking for adults aged 18 to 90 with ectopic Cushing syndrome. Participants will undergo various imaging tests to help locate the source of a hormone problem related to their condition.

Are You a Good Fit for This Trial?

You may be able to join if

  • I am between 18 and 90 years old.
  • I have been diagnosed with ectopic Cushing syndrome or may have it.
  • I can understand and sign a consent form.
  • I will use effective contraception if I am a woman of childbearing age.
  • I am willing to follow all study procedures.
  • I am available for the duration of the study.

You may not be able to join if

  • I am pregnant or breastfeeding.
  • I have a severe active infection.
  • I have serious heart or blood issues.
  • I have significantly low blood counts or liver problems.
  • I weigh more than 136 kg.
  • I had more than 450 ml of blood taken in the last six weeks.
  • I have had ten or more F-DOPA PET/CT scans or DOTATATE scans.

Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.

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Answer a few quick questions to see if you may meet the eligibility requirements.

Check Your Eligibility
About This Trial
Between 10% and 15% of patients with endogenous hypercortisolism (Cushing syndrome) have ectopic (non-pituitary) production of adrenocorticotropin hormone (ACTH) that causes cortisol excess. In approximately 50% of these patients, the tumoral source of ACTH cannot be found initially despite very detailed and extensive imaging, including studies such as computed tomography, magnetic resonance imagi…
Trial Locations
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Eligibility Criteria
* INCLUSION CRITERIA: To be eligible to participate in this study, an individual must meet all of the following criteria: * 18 - 90 years of age * Medical history of ectopic Cushing syndrome or diagnosed with the possibility of ectopic Cushing syndrome * For females of reproductive potential: agre…
Contacts

Raven N McGlotten, R.N.

(301) 827-0190

mcglottenr@mail.nih.gov

CONTACT

Lynnette K Nieman, M.D.

(301) 496-8935

niemanl@mail.nih.gov

CONTACT