We want to find out what happens to reproductive hormone levels; Luteinising Hormone (LH), Follicle Stimulating Hormone (FSH), testosterone and oestradiol when kisspeptin is administered to people for a period of 8 days each month, using either placebo (saline) or kisspeptin in doses of 0.1, 0.3 or 1.0 nmol/kg/hour.
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Eligibility Criteria
Inclusion criteria:
* Aged 18-60 years old
* Ability to give informed consent
* Secondary hypogonadism (or healthy participant)
Exclusion criteria:
* anaemia
* medical problems such as severe heart, kidney or liver disease
* blood donation in the last three months or intention to donate blood wit…
Inclusion criteria:
* Aged 18-60 years old
* Ability to give informed consent
* Secondary hypogonadism (or healthy participant)
Exclusion criteria:
* anaemia
* medical problems such as severe heart, kidney or liver disease
* blood donation in the last three months or intention to donate blood within 3 months of the end of the study
* needle phobia
* Poor venous access
* Active psychiatric illness
* Severe allergies
* Impaired ability to provide full consent to take part in the study
* Current alcohol or illicit drug dependence
* Current pregnancy or breast feeding
* Plans to conceive within 3 months of starting the study (barrier contraception must be used during and for 3 months after the end of the study)
* Arthritis or any impairment of hand coordination which would preclude using a hormone pump
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