Vasoactive Drugs for Treating Shock in ICU Patients
Vasoactive Drugs in Intensive Care Unit
Recruiting
Phase 4
Interventional Study
Shock
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Prior Safety Data
This treatment has already been tested in at least one earlier human trial.
At a Glance
- Age
- 18 and older
- Sex
- Any
- Trial phase
- Phase 4
- Study type
- Interventional
- Purpose
- Treatment
- Participants needed
- 836 (estimated)
- Sponsor
- University of Chicago · Other
Who this trial is looking for
This trial is looking for adults in the ICU who have shock that isn't improving with fluid treatment. Participants will receive either phenylephrine and vasopressin or norepinephrine and epinephrine to see which is safer for their heart rhythm.
Are You a Good Fit for This Trial?
You may be able to join if
- I am 18 years old or older
- I need vasoactive drugs through a central venous catheter for shock
- My average blood pressure is lower than 70 mmHg or my systolic blood pressure is lower than 100 mmHg despite fluids
You may not be able to join if
- I have had a cardiopulmonary arrest
- I am pregnant
- I have severe right heart failure
Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
Check Your Eligibility
About This Trial
The investigators hypothesis is that for ICU patients with shock, the use of the vasoactive drugs phenylephrine and vasopressin will reduce tachydysrhythmias when compared to norepinephrine and epinephrine. To investigate this hypothesis, the investigators are conducting a randomized double blind controlled trial comparing phenylephrine and vasopressin vs. norepinephrine and epinephrine in ICU pat…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
1. Age greater than or equal to 18 years old
2. Requirement for vasoactive drugs via a central venous catheter for the treatment of shock. Shock will be defined as mean arterial pressure less than 70 mmHg or systolic blood pressure less than 100 mmHg despite administration of at…
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