Immunologic Response to Pneumococcal Polysaccharide Vaccine in Splenic Injury Patients

Recruiting Phase 2 Interventional Study
Asplenia
No Placebo Group Every participant receives an active treatment — no one gets a placebo. Prior Safety Data This treatment has already been tested in at least one earlier human trial.
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At a Glance
Age
18 – 65
Sex
Any
Trial phase
Phase 2
Study type
Interventional
Purpose
Prevention
Participants needed
75 (estimated)
Sponsor
University of California, Davis · Other
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About This Trial
Persons without a spleen are susceptible to potentially lethal infections from certain bacteria, with pneumococcus being the most prevalent. Vaccines are provided to help protect against these infections, though they do not so with certainty. Trauma patients who sustain an injury to their spleen currently have three treatment options available for the treating surgeon - nonoperative management, em…
Trial Locations
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Eligibility Criteria
Inclusion Criteria: * Adult trauma patients (aged 18 to 65 years old) sustaining a splenic injury. Exclusion Criteria: * Ages less than 18 and greater than 65 * Initial planned nonoperative management patient who subsequently undergoes embolization or splenectomy will be withdrawn from the study.
Contacts

David V Shatz, MD

916-734-5535

dvshatz@ucdavis.edu

CONTACT

Anthony Calabro, PhD

916-734-4365

arcalabro@ucdavis.edu

CONTACT