No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
18 and older
Sex
Any
Study type
Observational
Participants needed
900 (estimated)
Sponsor
Tammie L. S. Benzinger, MD, PhD · Other
Who this trial is looking for
This trial is looking for adults to help researchers understand brain tau levels in Alzheimer's disease. Participants will undergo brain scans and other tests to see how tau relates to thinking skills.
Are You a Good Fit for This Trial?
You may be able to join if
I am at least 18 years old.
I am cognitively normal or have mild dementia.
I can undergo tests like MRI or CT scans and PET scans.
I am willing to take a pregnancy test if I am a pre-menopausal woman.
You may not be able to join if
I have a condition that would make it hard for me to complete the tests.
I cannot lie still for long periods during the scans.
I am taking medications that can prolong the QT interval.
I am hypersensitive to F 18 T807 or its ingredients.
I have severe claustrophobia.
I am currently pregnant or breastfeeding.
I am on anticoagulants if I choose to have a lumbar puncture.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
A single-center, open-label baseline controlled imaging study designed to assess whether brain tau fibril uptake of flortaucipir as measured by PET correlates with cognitive status of individuals with and without brain tau fibrils.
Trial Locations
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Status
Eligibility Criteria
Inclusion Criteria:
1. Male or female participants, at least 18 years of age.
2. Cognitively normal, or with mild dementia, as assessed clinically
3. Participant is able and willing to undergo testing (MRI or CT, PET, radioactive tracer injection, LP; for those unable to undergo an MRI, CT will be …
Inclusion Criteria:
1. Male or female participants, at least 18 years of age.
2. Cognitively normal, or with mild dementia, as assessed clinically
3. Participant is able and willing to undergo testing (MRI or CT, PET, radioactive tracer injection, LP; for those unable to undergo an MRI, CT will be used to generate regions-of-interest).
4. Pre-menopausal women will undergo a urine pregnancy test within 24 hours of drug administration.
Exclusion Criteria:
1. Has any condition that, in the Investigator's opinion, could increase risk to the participant, limit the participant's ability to tolerate the experimental procedures, or interfere with the collection/analysis of the data (for example, participants with severe chronic back pain might not be able to lie still during the scanning procedures).
2. Is deemed likely unable to perform the imaging procedures for any reason.
3. Has a high risk for Torsades de Pointes or is taking medications known to prolong QT interval.
4. Has hypersensitivity to F 18 T807 or any of its excipients.
5. Contraindications to PET, PET-CT or MR (e.g. electronic medical devices, inability to lie still for long periods) that make it unsafe for the individual to participate.
6. Severe claustrophobia.
7. Currently pregnant or breast-feeding.
8. For those electing to undergo the optional lumbar puncture: currently on anticoagulant of any form -
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