Study of Orphenadrine' in the Treatment of Muscle Cramps in Patients With Cirrhosis
Recruiting
Phase 3
Interventional Study
Liver Cirrhosis
Muscle Cramps
Pivotal Trial
This treatment is in the last trial phase before FDA approval.
Prior Safety Data
This treatment has already been tested in at least one earlier human trial.
At a Glance
- Sex
- Any
- Trial phase
- Phase 3
- Study type
- Interventional
- Purpose
- Treatment
- Participants needed
- 100 (estimated)
- Sponsor
- Sherief Abd-Elsalam · Other
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About This Trial
Muscle cramps are common in patients with liver disease and associated with significantly diminished quality of life. Patients with cirrhosis often experience muscle cramps with varied frequency and severity. The exact mechanisms by which they occur remain unclear, although a number of pathophysiological events unique to liver disease may contribute. Clinical studies have identified alterations in…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Cirrhosis
* Muscle cramps( ≥3 cramps per week )
Exclusion Criteria:
* • Allergy to orphenadrine
* Renal impairment
* Pregnant and lactating women
* Peripheral vascular disease
* Peripheral neuropathy
* Medications as calcium channel blockers, conjugated estrogens …
Contacts