Sirolimus for LAM Treatment

Safety and Durability of Sirolimus for Treatment of LAM

Recruiting Observational Study
Lymphangioleiomyomatosis
No Placebo Group Every participant receives an active treatment — no one gets a placebo. No Study Drug Researchers observe your health over time — no experimental treatment is given.
Ready to participate?

Review the details below, then apply to join this clinical trial.

At a Glance
Age
18 and older
Sex
Female
Study type
Observational
Participants needed
600 (estimated)
Sponsor
University of Cincinnati · Other
Who this trial is looking for

This trial is looking for male and female adults diagnosed with LAM. Participants will have the option to take sirolimus or other mTOR inhibitors as part of their treatment.

Are You a Good Fit for This Trial?

You may be able to join if

  • I am 18 years old or older
  • I have been diagnosed with LAM
  • I can give informed consent
  • I am currently on therapy or have been treated with mTOR inhibitors

You may not be able to join if

  • I cannot attend at least one clinic visit per year
  • I cannot give informed consent
  • I am unable or unwilling to perform lung function tests

Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.

Think this trial could be right for you?

Answer a few quick questions to see if you may meet the eligibility requirements.

Check Your Eligibility
About This Trial

The MIDAS study aims to follow male and female LAM patients who are currently taking, have previously failed or been intolerant of, or may (at some time in the future) take mTOR inhibitors (sirolimus or everolimus) as part of their clinical care. Adult female TSC patients may also enroll, with or without lung cysts.

Trial Locations
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Eligibility Criteria
Inclusion Criteria: * Female or male, age 18 or over * Diagnosis of LAM based on ATS/JRS criteria * Signed and dated informed consent * On chronic therapy, newly treated or may be considered for therapy with mTOR inhibitors or previously intolerant of or having failed mTOR inhibitor therapy Exclus…
Contacts

Susan McMahan Sellers, BSN, RN

(513) 558-4376

susan.mcmahan@uc.edu

CONTACT

Francis X McCormack, MD

(513) 558-0588

frank.mccormack@uc.edu

CONTACT