Cognitive Decline Study for Late Life Depression
Characterizing Cognitive Decline in Late Life Depression: The ADNI Depression Project
Recruiting
Observational Study
Major Depression
Late Life Depression (LLD)
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
At a Glance
- Age
- 65 and older
- Sex
- Any
- Study type
- Observational
- Participants needed
- 120 (estimated)
- Sponsor
- University of Southern California · Other
Who this trial is looking for
This trial is looking for individuals with late life depression to understand how it affects thinking and memory. Participants will undergo brain scans and provide health information over a 30-month period.
Are You a Good Fit for This Trial?
You may be able to join if
- I participated in the original Cognitive Decline study
- I am experiencing late life depression
You may not be able to join if
- I have not had stable antidepressant medication for 4 weeks before the MRI scan
- I have not completed 4 weeks of psychotherapy before the MRI scan
Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.
Think this trial could be right for you?
Answer a few quick questions to see if you may meet the eligibility requirements.
Check Your Eligibility
About This Trial
The purpose of this research study is to characterize the mechanisms contributing to cognitive impairment and accelerated cognitive decline in Late Life Depression (LLD).
This is a non-randomized, observational, non-treatment study that originally launched in 2015, enrolling 133 participants. From the originally enrolled participants, the continuation of the ADNI-D study will enroll 120 participa…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
1\. Individual participated in original Characterizing Cognitive Decline in Late Life Depression study or Multimodal MRI Characteristics of Psychotherapy Response in Late Life Depression Study.
Exclusion Exceptions:
1. Antidepressant medication treatment is allowed only if the…
Contacts