Placental Passage and Disposition of Drugs: A Physiology-based Approach
Recruiting
Observational Study
Pregnancy
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
At a Glance
- Age
- 18 and older
- Sex
- Female
- Study type
- Observational
- Participants needed
- 2,000 (estimated)
- Sponsor
- Radboud University Medical Center · Other
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About This Trial
The investigators aim to integrate the outcomes in physiology-based pharmacokinetic (PBPK) models to put the generated data into context with medical conditions that require maternal or fetal drug therapy (e.g. HIV). These models will be validated with available 'real-life' maternal and fetal PK data, such as data from the PANNA network.
PBPK models of drug therapy during pregnancy will provide a…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Female
* Age \> 18
* Signed informed consent
* \>38 weeks pregnant
Exclusion Criteria:
* Retained placenta
* HIV infected
* Known hepatitis C infection
* Multiple pregnancy
* Congenital birth defects child
* Sectio EXIT procedure
Contacts