Role of Sympathetic Overactivity and Angiotensin II in PTSD and CV
Recruiting
Phase 2
Interventional Study
Stress Disorders, Post-Traumatic
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Prior Safety Data
This treatment has already been tested in at least one earlier human trial.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
At a Glance
- Age
- 18 – 65
- Sex
- Any
- Trial phase
- Phase 2
- Study type
- Interventional
- Purpose
- Prevention
- Participants needed
- 134 (estimated)
- Sponsor
- Emory University · Other
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About This Trial
The purpose of this study is to find out why patients with post-traumatic stress disorder (PTSD) have an increased risk for heart disease and high blood pressure later in life. A second purpose is to find out what causes PTSD patients to have high adrenaline levels during stress. This study will also test if a medicine called losartan improves high adrenaline levels in patients with PTSD and if a …
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* veterans ages 18-65 years old with PTSD and without PTSD (controls) matched for age, gender, and race.
Exclusion Criteria:
* pregnancy
* hypertension
* diabetes
* heart or vascular disease
* illicit drug use
* excessive alcohol use (\>2 drinks per day)
* hyperlipidemia
* aut…
Contacts