Aging, Geriatric Syndromes and Clonal Hematopoiesis

Inclusion Criteria: * At least 50 years of age. * Able to understand written and spoken English. * Able to understand and willing to sign an IRB-approved written informed consent document (or that of a legally authorized representative, if applicable for the trauma cohort) Exclusion Criteria: * Inability or unwillingness to complete health questionnaire (with the exception of hip and knee replacement participants). * History of a recent (\<30 days) acute viral illness. * Current cancer diagnosis and currently receiving chemotherapy or undergoing radiation therapy. A prior history of cancer is allowed if the participant completed therapy \> 1 year prior to enrollment; participants with a prior diagnosis of cancer will be asked to sign a release of information for the research team to obtain records regarding their prior cancer treatment. * Current use of drugs that cause DNA damage (e.g. Cytoxan, azathioprine, etc.) for the treatment of a non-malignant disease. * Vulnerable populations (e.g. prisoners). * Known infection with Hepatitis B or C, HTLV, or HIV. * Additional exclusion for optional bone marrow aspirate/biopsy substudy: * Use of medications for anticoagulation or "blood thinning" including warfarin, low molecular weight heparins (enoxaparin, daltaparin) or direct-acting oral anticoagulants (dabigatran, rivaroxaban, apixaban, edoxaban or betrixaban) * allergy to lidocaine or other local anesthetics.