CSF Sample Collection for Huntington's Disease
HDClarity: a Multi-site Cerebrospinal Fluid Collection Initiative to Facilitate Therapeutic Development for Huntington's Disease
Recruiting
Observational Study
Huntington's Disease
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
At a Glance
- Age
- 11 – 75
- Sex
- Any
- Study type
- Observational
- Participants needed
- 2,500 (estimated)
- Sponsor
- University College, London · Other
Who this trial is looking for
This trial is looking for people with Huntington's disease at different stages. Participants will provide samples of cerebrospinal fluid and plasma for research to help develop new treatments for the disease.
Are You a Good Fit for This Trial?
You may be able to join if
- I am between 18 and 75 years old and have Huntington's disease.
- I can provide consent or have a legal representative.
- I can follow the study procedures.
- I have had a genetic test for Huntington's disease.
You may not be able to join if
- I have participated in a drug trial within the last 30 days.
- I have changed my medication for Huntington's disease within the last 30 days.
- I have taken antiplatelet or anticoagulant therapy in the last 14 days.
- I have significant health issues that could affect my participation.
- I am afraid of needles or have had recent spinal surgery.
- I have a bleeding or bruising disorder.
- I have had a serious problem related to the study or lumbar puncture in the last 30 days.
- I am pregnant or have tested positive for pregnancy.
Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.
Think this trial could be right for you?
Answer a few quick questions to see if you may meet the eligibility requirements.
Check Your Eligibility
About This Trial
HDClarity will seek at least 2500 research participants at different stages of Huntington's disease (HD). The primary objective is to collect a high quality CSF sample for evaluation of biomarkers and pathways that will enable the development of novel treatments for HD. The secondary objective is to generate a high quality plasma sample collection matching the CSF collections, which will also be u…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Age (18-75 years controls, early/late premanifest HD and incomplete penetrance HD, 21-75 years early/moderate/advanced manifest HD, ≥11 years juvenile HD)
* Enroll HD participant
* Capable of consenting or have a legal representative (parent/guardian for juveniles)
* Capable o…
Contacts