No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
4 – 18
Sex
Any
Study type
Observational
Participants needed
500 (estimated)
Sponsor
Stanford University · Other
Who this trial is looking for
This trial is looking for children with Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS) to study the brain and immune system. Participation involves providing information about their symptoms and health history.
Are You a Good Fit for This Trial?
You may be able to join if
I have been diagnosed with PANS.
I am aged 1-18 at the start of my symptoms.
My symptoms started suddenly with OCD or food restriction.
I have at least two other symptoms like frequent urination or inattention.
I live within 90 miles of Stanford University.
I have had a pediatrician for the last 3 years within 90 miles of Stanford.
You may not be able to join if
I have any other neuropsychiatric illness that may confuse the diagnosis.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
This study is an investigation of the neurologic, immunologic, and rheumatologic markers of Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS). PANS is a condition characterized by the abrupt, dramatic onset of obsessive compulsive disorder (OCD) and/or eating restriction accompanied by equally abrupt and severe co-morbid neuropsychiatric symptoms, which include anxiety, emotional lability, de…
This study is an investigation of the neurologic, immunologic, and rheumatologic markers of Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS). PANS is a condition characterized by the abrupt, dramatic onset of obsessive compulsive disorder (OCD) and/or eating restriction accompanied by equally abrupt and severe co-morbid neuropsychiatric symptoms, which include anxiety, emotional lability, depression, irritability, aggression, oppositionality, deterioration in school performance, behavioral (developmental) regression, sensory amplification, movement abnormalities, sleep disturbance, and urinary frequency. PANS is thought to be caused by infection, inflammation, or alternate triggers that is associated with a brain response that leads to these symptoms. The purpose of this study is to examine specific neurologic, immunologic, rheumatologic, and genomic, components in children with the acute-onset of psychiatric symptoms. This research may begin to uncover a much larger story of autoimmune processes that are involved in psychiatric disorders of childhood. By better understanding the etiologic components of psychiatric phenomenon, future treatments may be better targeted to underlying causes.
Trial Locations
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Status
Eligibility Criteria
Inclusion Criteria:
* Children with PANS
1. Age 1-18 at onset of PANS
2. Diagnosis of PANS: abrupt onset of OCD or food restriction, and at least two of the following associated symptoms: frequent urination, worsening handwriting/cognition, inattention, anorexia, separation anxiety, opposition…
Inclusion Criteria:
* Children with PANS
1. Age 1-18 at onset of PANS
2. Diagnosis of PANS: abrupt onset of OCD or food restriction, and at least two of the following associated symptoms: frequent urination, worsening handwriting/cognition, inattention, anorexia, separation anxiety, oppositionality, irritability/rage outbursts, and emotional lability.
3. Patients must live within 90 miles of Stanford University and have a new onset of PANS illness
4. Patients must have an established pediatrician within 90 miles of Stanford University for 3 years.
* Healthy Controls
1. Age 4-18
2. No psychiatric diagnosis
Exclusion Criteria:
* Any neuropsychiatric illness that may obscure the clear diagnosis of PANS
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