Mycophenolate Mofetil vs Cyclophosphamide for Lupus Nephritis
The Effect of Mycophenolate Mofetil and Cyclophosphamide on the Lymphocyte Subsets in Patients With Proliferative Lupus Nephritis
Recruiting
N/A
Interventional Study
Lupus Nephritis
At a Glance
- Age
- 18 – 80
- Sex
- Any
- Study type
- Interventional
- Purpose
- Basic Science
- Participants needed
- 50 (estimated)
- Sponsor
- The University of Hong Kong · Other
Who this trial is looking for
This trial is looking for patients with a specific type of kidney inflammation due to lupus. Participants will receive different treatments for 6 months, and their immune system responses will be monitored.
Are You a Good Fit for This Trial?
You may be able to join if
- I have been diagnosed with lupus nephritis.
- I have active kidney issues shown by high protein in my urine or increased creatinine.
- I am willing to give informed consent.
You may not be able to join if
- I have taken certain immunosuppressive medications in the last 3 months.
- I have received biologic treatments in the last 12 months.
- I am pregnant or breastfeeding.
Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.
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Answer a few quick questions to see if you may meet the eligibility requirements.
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About This Trial
This study investigated the effect of mycophenolate mofetil and cyclosphosphamide on lymphocyte subsets in patients with proliferative lupus nephritis. Patients with biopsy-proven Class III/IV+/-V LN were randomized to received: 1) prednisolone (0.8mg/kg/day) plus CTX (1.5-2mg/kg/d) for 6 months) followed by Azathioprine (AZA) (1-1.5mg/kg/d) maintenance; OR 2) prednisolone (0.8mg/kg/d) plus MMF (1…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
\- 1. Patients with biopsy proven Class III/IV+/-V LN (ISN/RPS classification) and active nephritis as indicated by an increase of proteinuria \>1g/day and/or rise in serum creatinine by \>15% compared with baseline, with or without serological reactivation.
2\. Willing to give…
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