No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
18 and older
Sex
Any
Study type
Observational
Participants needed
76 (estimated)
Sponsor
Douglas Scharre · Other
Who this trial is looking for
This trial is looking for people with Alzheimer's disease, Lewy Body dementia, or Parkinson's disease. Participants will undergo various assessments to help distinguish between these conditions.
Are You a Good Fit for This Trial?
You may be able to join if
I have been diagnosed with Alzheimer's disease, Lewy Body dementia, or Parkinson's disease.
I have a Mini Mental State Examination score of 10 or higher.
I have a reliable study partner who is in regular contact with me.
I have been taking my medication consistently for the last four weeks.
I can see and hear well enough for testing.
You may not be able to join if
I have another medical condition that affects my dementia.
I have an active medical disorder that prevents me from participating.
I am pregnant or breastfeeding.
I have severe kidney problems.
English is not my first language.
I have less than 12 years of education.
I have taken part in a study involving an amyloid targeting agent.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
The study is designed to characterize the clinical, neuropsychological, polysomnographic, and neuroimaging findings among subjects with Alzheimer's disease, Lewy Body dementia, and Parkinsons' Disease.
Trial Locations
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Status
Eligibility Criteria
Inclusion Criteria:
* Subjects must meet the standard clinical criteria of the syndromes of interest
* All subjects must have enough cognitive abilities to complete study procedures, which will be operationally defined as having a Mini Mental State Examination (MMSE) score greater or equal to 10.
*…
Inclusion Criteria:
* Subjects must meet the standard clinical criteria of the syndromes of interest
* All subjects must have enough cognitive abilities to complete study procedures, which will be operationally defined as having a Mini Mental State Examination (MMSE) score greater or equal to 10.
* Subjects must be on stable cognitive and psychoactive medication regimen for the preceding four weeks of enrollment.
* Subjects must have a responsible study partner that either lives with them or is in regular contact with them at least 4 out of 7 days per week.
* Subjects must have visual and auditory acuity adequate for testing.
Exclusion Criteria:
* Any other condition (other than the primary diagnosis), which in the opinion of the investigators might contribute to the syndrome of dementia or complicate its assessment.
* active medical disorder that could preclude participation in this protocol
* Women who are pregnant or are breast feeding
* severe renal impairment as defined by glomerular filtration rate (GFR) less than 30 (may have increased radiation exposure with the DaTscan).
* Subjects in whom English is not the 1st language
* Subjects with educational level less than 12 years
* Subjects who have ever participated in an experimental study with an amyloid targeting agent unless it can be documented that the subject received only placebo during the course of the trial.
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