Microbiome and Sarcopenia in Patients With Liver Cirrhosis
Recruiting
N/A
Interventional Study
Sarcopenia
Liver Cirrhosis
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
At a Glance
- Age
- 18 – 100
- Sex
- Any
- Study type
- Interventional
- Purpose
- Basic Science
- Participants needed
- 120 (estimated)
- Sponsor
- Medical University of Graz · Other
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About This Trial
Protein-energy malnutrition (PEM) occurs in 65-90% of patients with liver cirrhosis. Severity of malnutrition correlates with progression of liver disease and leads to sarcopenia in 30-70% of cirrhotic patients. Malnutrition and sarcopenia are associated with an increased risk of complications and mortality.
In cirrhosis the gut microbiome is altered leading to increased gut permeability, bacteri…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Hospitalized patients for any reason with clinical/radiological/histological diagnosis of cirrhosis
* Age \>18y
* Informed consent
* CT/MRI scan within +/-14 days of the baseline study visit
Exclusion Criteria:
* Hepatic encephalopathy \> grade 2 and or other cognitive disor…
Contacts