Effect of Levosulpiride on Retinal Alterations in Patients With Diabetic Retinopathy and Diabetic Macular Edema

Inclusion Criteria: * Age equal or greater than 40 years but no older than 69 years * Male and female subjects with mild and moderate diabetic macular edema (DME), non-proliferative diabetic retinopathy (DR), and with proliferative DR undergoing medically prescribed vitrectomy. * Signing informed consent * Without ocular complications: severe myopia (\> 6 diopters), ocular media opacity, retinal detachment, etc. * Without previous ocular treatments: ocular surgeries, retinal laser photocoagulation, intravitreal administration of antiangiogenic agents (delivered \< 6 months before enrollment). * Prolactin serum levels ≤ 20 ng/ml * With normal or mild loss of kidney function (glomerular filtration rate \>60 ml/min) for groups with DME and DR without vitrectomy. * With mild to severe loss of kidney function (glomerular filtration rate \>30 ml/min) for groups with DR undergoing vitrectomy. * Without contraindications for the use of levosulpiride (Parkinson disease, epilepsy, breast cancer, alcoholism, hypokalemia). * Without hyperprolactinemia inducing conditions: Pathologies (hypothyrodism, hepatic dysfunction, prolactinomas); Medication (antipsychotics, antidepressants, prokinetics, other) Exclusion Criteria: * Not meeting inclusion criteria. * Adverse and intolerable drug effects. * Not complying with study medication * Inability to continue in-hospital appointments. * Missing outcome data * Hesitation to continue with study medication * Relocation to another state or country * Voluntary withdrawal of consent