The preSPG4 Study - Studying the Prodromal and Early Phase of SPG4
Recruiting
N/A
Interventional Study
Hereditary Spastic Paraplegia
Hereditary, Spastic Paraplegia, Autosomal Dominant
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
At a Glance
- Age
- 18 – 70
- Sex
- Any
- Study type
- Interventional
- Purpose
- Diagnostic
- Participants needed
- 200 (estimated)
- Sponsor
- University Hospital Tuebingen · Other
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About This Trial
Study goals 1. Prospective longitudinal data on progression in the natural course of SPG4 in presymptomatic mutation carriers prior to clinical disease onset and in early stages of disease 2. Biomarkers providing objective measures of disease activity
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* First degree relatives (parents, offspring, and sibs) of SPG4 patients or symptomatic individuals with known SPAST mutation
* Age 18 to 70 years
* Written, informed consent (patient)
Exclusion Criteria:
* No known SPAST-mutation within the family
* Manifest spastic gait (sub…
Contacts