Specific Oral Tolerance Induction (SOTI) to Children With IgE-mediated Wheat Allergy

Inclusion Criteria: 1. Age 2-16 years 2. Personal history of IgE-mediated allergy to wheat with unequivocal allergic reaction one year before study entry, and 1. Positive SPT in wheat (\> 3 mm), and/or 2. Wheat specific IgE f4 \> 0.35 kUa/L, and 3. A positive Oral Food Challenge (OFC) to wheat, with the exception of patients who report a recent reaction (\< 3 months before study entry) after the consumption of wheat products 3. Signed written consent form of the parents. Exclusion Criteria: 1. Severe persistent or uncontrolled bronchial asthma or other lung disease (other than asthma), and/or 2. Recent personal history (over the past 12 months) of severe anaphylactic reaction following wheat consumption, for which Intensive Care Unit (ICU) hospitalization was required, and/or 3. Patients on specific immunotherapy, subcutaneous (SCIT) or sublingual (SLIT) or any other form of current immunotherapy or treatment with other biological agents, and/or 4. Personal history of anaphylaxis due to wheat-dependent exercise induced anaphylaxis, and/or 5. Patients with celiac disease or diagnosis other than IgE-mediated wheat allergy (eg eosinophilic gastrointestinal diseases), and/or 6. Patients with cardiovascular disease or other significant systemic disease, and/or 7. Patients presenting severe anaphylactic reaction to very low doses of wheat (eg. after administration of the 1st or 2nd dose during the baseline OFC).