Engineered Immune Effectors Against Cervical Cancer
Recruiting
Phase 1Phase 2Interventional Study
Cervical Cancer
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Prior Safety Data
This treatment has already been tested in at least one earlier human trial.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
10 – 80
Sex
Female
Trial phase
Phase 1/2
Study type
Interventional
Purpose
Treatment
Participants needed
20 (estimated)
Sponsor
Shenzhen Geno-Immune Medical Institute · Other
Who this trial is looking for
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Answer a few quick questions to see if you may meet the eligibility requirements.
The primary objective of this study is to evaluate the safety of cervical cancer specific engineered immune effectors (CC-EIEs). The secondary objectives are to evaluate the rate of successful CC-EIE generation in vitro and determine the anti-CC efficacy.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
1. Written, informed consent obtained prior to any study-specific procedures.
2. Age older than 10 years.
3. Eastern Cooperative Oncology Group (ECOG) PS of 0 or 1.
4. Expected survival ≥ 12 weeks.
5. Not pregnant, and on appropriate birth control if of childbearing potential.
6…
Inclusion Criteria:
1. Written, informed consent obtained prior to any study-specific procedures.
2. Age older than 10 years.
3. Eastern Cooperative Oncology Group (ECOG) PS of 0 or 1.
4. Expected survival ≥ 12 weeks.
5. Not pregnant, and on appropriate birth control if of childbearing potential.
6. Evidence of high-risk HPV infection.
7. Stage III-IV or recurrent cervical cancer.
8. Initial hematopoietic reconstitution with
* neutrophils (ANC) ≥ 1,000/mm\^3;
* platelet (PLT) ≥ 100,000/mm\^3.
9. Proper renal and hepatic functions (ULN denotes "upper limit of normal range") with
* serum creatinine ≤ 2×ULN;
* serum bilirubin ≤ 2×ULN;
* AST/ALT ≤ 2×ULN;
* ALKP ≤ 5×ULN;
* serum bilirubin. 2.0 is acceptable in the setting of known Gilbert's syndrome.
10. Human immunodeficiency virus (HIV) and Hepatitis C virus (HCV) test negative.
Exclusion Criteria:
1. Patients with
* cervical benign lesions: cervical columnar epithelium ectopic, cervical polyps, cervical endometriosis and cervical tuberculous ulcers;
* cervical benign tumors: cervical submucous myoma, cervical cancer, cervical papilloma.
2. Patients with evidence of abdominal free air not explained by paracentesis or recent surgical procedure (prior, current or planned treatment).
3. Previous exposure to mouse SCC antibody.
4. Current or recent treatment (within the 28-day period prior to Day 0) with another investigational drug or previous participation in this study.
5. Minor surgical procedures within 2 days prior to Day 0 (including central venous access device placement for chemotherapy administration, tumor biopsies, needle aspirations).
6. Pregnant or lactating females.
7. Inadequate bone marrow function with
* absolute neutrophil count \< 1,000/mm\^3;
* platelet count \< 100,000/mm\^3;
* Hb \< 9 g/dL.
8. Inadequate liver and renal function with
* serum (total) bilirubin \> 1.5 x ULN;
* AST \& ALT \> 2.5 x ULN (\> 5 x ULN in patients with liver metastases);
* alkaline phosphatase \> 2.5 x ULN;
* serum creatinine \>2.0 mg/dl (\> 177 μmol/L);
* urine dipstick for protein uria should be \< 2+. Patients with ≥ 2+ proteinuria on dipstick urinalysis at baseline should undergo 24 hour urine collection and must demonstrate \< 1 g of protein/24 hr.
9. Serious active infection requiring i.v. antibiotics at during screening.
10. Subject actively infected with HCV (HCV antibody positive), HBV (HBsAg positive), HIV (HIV antibody positive), HTLV (HTLV antibody positive), Treponema pallidum antibody positive or TB culture positive.
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