Liver X Receptor (LXR) as a Novel Therapeutic Target in Diabetic Retinopathy (DR)
Recruiting
Observational Study
Diabetic Retinopathy
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
At a Glance
- Age
- 21 – 98
- Sex
- Any
- Study type
- Observational
- Participants needed
- 104 (estimated)
- Sponsor
- University of Alabama at Birmingham · Other
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About This Trial
Results from large clinical trials demonstrate a strong association between lipid abnormalities and progression of the most common microvascular complication, diabetic retinopathy (DR). We found that activation of a master regulator of cholesterol metabolism, the nuclear hormone receptors liver X receptors (LXRα/LXRβ), prevents DR in rodent models. In this application, we seek to understand the me…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Any man or woman between the ages of 21- 98 years of age will be eligible to participate. To participate in the study as a study subject we will require: a) the subject must either carry the diagnosis of diabetes or be a healthy aged control and b) the patient be willing and h…
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