Valid Biomarkers in Blood to Predict the Response to Therapy in Prostate Cancer Patients

Inclusion Criteria: General inclusion criteria (for entering all groups) * Age ≥ 18 years * Histological diagnosis of prostate adenocarcinoma at different stages of disease (see Section 6.2) for which a treatment is indicated * Written Informed Consent Inclusion criterion only for entering Group 0 • Patients with a known diagnosis of CSPC or CRPC Inclusion criterion only for entering Group 1a • Patients that underwent biopsies for a suspect of PC, but resulted negative for cancer Exclusion Criteria: General exclusion criteria (for entering all groups) * Active infection requiring treatment * Decrease of general condition * Concomitant severe comorbities * Difficult socioeconomic conditions making regular follow up unfeasible. * Need of concomitant steroids at study entry and during the study * Diagnosis of second tumor in the previous 5 years Exclusion criterion only for entering Group 0 • No antibiotic treatments in the previous 2 months before enrollment Exclusion criteria only for entering Group 1 * Previous radical surgery and / or radical radiotherapy * Previous hormonal treatments Exclusion criteria only for entering Group 2 * No antibiotic treatments in the previous 2 months before enrollment (only in patients enrolling also for metagenomics and metabolomics) * Previous hormonal treatments for advanced disease Exclusion criterion only for entering Group 3 • No antibiotic treatments in the previous 2 months before enrollment (only in patients enrolling also for metagenomics and metabolomics analyses)