Study of Biomarkers in Gynecological Cancers

Pre-Screening Eligibility: Inclusion Criteria: * Patients with probable diagnoses of gynecological malignancy (ovarian, tubal, primary peritoneal, uterine, cervical, vulvar and rare gynecological cancers) and confirmed to be undergoing upfront debulking surgery/radiation * Patient must be ≥16 years of age at the time of consent. * Ability to understand and provide written informed consent. * ECOG Performance Status ≤ 2. * Patient must consent to provide tissue sample from surgery and blood samples * Life expectancy ≥3 months. Exclusion Criteria: * Patients must be treatment naïve (no previous treatment of Neoadjuvant chemotherapy nor radiation for newly diagnosed disease) Eligibility for Patients with Gynecological Diagnosis Inclusion Criteria: * Patients with histological confirmation of gynecological malignancy (except ovarian cancer with high grade serous histology, tubal, primary peritoneal, uterine, cervical, vulvar and vaginal cancer and rare gynecological cancers). * Patient must be ≥16 years of age at the time of consent. * Ability to understand and provide written informed consent. * Eastern Cooperative Oncology Group (ECOG) Performance Status ≤ 2. * Patient must consent to providing archival tissue and/or to undergo tumour biopsy and/or to provide blood or fluid collection samples. Patients will also be asked to provide a blood sample for germline mutation analysis. * Life expectancy ≥3 months. * No limits of previous lines of treatment. Exclusion Criteria: * Any contraindication to tumour biopsy or blood collection * Patient with diagnosis of High grade serous Ovarian Cancer are excluded