Mevrometostat for Castration Resistant Prostate Cancer

A Study of Mevrometostat for Treatment of Relapsed/Refractory SCLC, Castration Resistant Prostate Cancer, and Follicular Lymphoma

Recruiting Phase 1 Interventional Study
Metastatic Castration Resistant Prostate Cancer (mCRPC) Small Cell Lung Cancer (SCLC) Follicular Lymphoma (FL)
No Placebo Group Every participant receives an active treatment — no one gets a placebo.
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Review the details below, then apply to join this clinical trial.

At a Glance
Age
18 and older
Sex
Any
Trial phase
Phase 1
Study type
Interventional
Purpose
Treatment
Participants needed
453 (estimated)
Sponsor
Pfizer · Industry
Who this trial is looking for

This trial is looking for men with Castration Resistant Prostate Cancer who have already received treatment but their cancer has progressed. Participants will receive the study medicine Mevrometostat and may take other medications as part of the trial.

Are You a Good Fit for This Trial?
Rules you out History of CHFVentricular dysfunctionFructose intolerance

You may be able to join if

  • I have been diagnosed with castration resistant prostate cancer.
  • I have a performance status of 0-2 and can expect to live at least 6 months.
  • I have good bone marrow, kidney, and liver function.

You may not be able to join if

  • I have had radiation treatment to more than 25% of my bone marrow.
  • I have a QTcF interval longer than 480 msec.
  • I have uncontrolled high blood pressure.
  • I am allergic to Mevrometostat or enzalutamide.
  • I have an active gastrointestinal disease or chronic diarrhea.
  • I am currently taking strong or moderate CYP3A4 inducers or inhibitors.
  • I have taken enzalutamide in the last 4 weeks.

Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.

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About This Trial
The purpose of this study is to learn about the safety and effects of the study medicine (called Mevrometostat) for the possible treatment of Relapsed/ Refractory Small Cell Lung Cancer (SCLC), Castration Resistant Prostate Cancer (CRPC) and Follicular Lymphoma (FL). The study consists of 3 parts; Part 1 and 2 enrolled participants with SCLC, metastatic CRPC, and FL are closed for enrollment. Par…
Trial Locations
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Eligibility Criteria
Part 1 and Part 2 (Closed for enrollment). Part 3 Key Inclusion Criteria: * Histological or cytological diagnosis of castration resistant prostate cancer. * Eastern Cooperative Oncology Group (ECOG) Performance Status (PS) of 0-2 with expected life expectancy of at least 6 months. * Adequate bone …
Contacts

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