A Randomized Controlled Study Evaluating Bariatric Surgery as a Treatment for Severe NASH With Advanced Liver Fibrosis in Non-severe Obese Patients

Recruiting N/A Interventional Study
Surgery Obesity NASH - Nonalcoholic Steatohepatitis Cirrhosis
No Placebo Group Every participant receives an active treatment — no one gets a placebo.
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At a Glance
Age
18 – 65
Sex
Any
Study type
Interventional
Purpose
Treatment
Participants needed
100 (estimated)
Sponsor
University Hospital, Lille · Other
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About This Trial

The aim of the study is to demonstrate the superiority of bariatric surgery on the disappearance of NASH without worsening of fibrosis in comparison to medical standard treatment in obese patients (35 kg/m² \> BMI ≥ 30 kg/m²) with NASH complicated of advanced fibrosis (F3 and F4 fibrosis grade according to Brunt score).

Trial Locations
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Eligibility Criteria
Inclusion Criteria: * Provide written informed consent and agree to comply to the study protocol prior to enrolment. * BMI and Brunt Fibriosis score: * For F3 fibrosis patients: 35\>BMI≥ 30kg/m² ; Fibroscan ≥ 9kPa or FibrometreVM ≥0.526 predicting a F3 fibrosis score grade within 1 month before …
Contacts

Philippe Mathurin, MD,PhD

3 20 44 53 21

philippe.mathurin@chru-lille.fr

CONTACT

Guillaume Lassailly, MD

3 20 44 53 21

guillaume.lassailly@chru-lille.fr

CONTACT