Intra-articular Platelet-Rich Plasma Compared With Viscosupplementation in the Treatment of Knee Osteoarthritis

Inclusion Criteria: * Ability to provide informed consent * Chronic pain (\>3 months) * Grade 2 -3 according to Kellgren- Lawrence (K-L) classification system (using bilateral anteroposterior radiograph image acquired while the patient is weight-bearing with both knees in full extension) * Minimum score of 40 out of possible 100 on the VAS (Visual Analog Scale) for pain * Age 18 to 75 years old * Physical exam and medical history * Complete Blood Count to include platelets and differential (CBC with Diff) within normal limits * C-Reactive Protein (CRP) within normal limits * Sed Rate (ESR) within normal limits * Survey of current medications Exclusion Criteria: * Presence of major axial deformity (\>5° valgus or varus deviation) * Surgery on target knee within 12 months prior to scheduled treatment * Autoimmune disorder * Active infections * Immuno-suppression (e.g., AIDS, etc.) * Anti-coagulant therapy * Use of NSAIDs 5 days prior to blood draw or up to 7 days after last PRP / HA treatment * Hemoglobin (Hg) \<12 g/dL * Platelet counts (PLT) \<150,000 /mm3 * Previous infiltrative treatment within 3 weeks prior to scheduled treatment * Pregnancy/Breastfeeding * Hypersensitivity to HA * Inability to complete an MRI due to metal implants or claustrophobia * Diabetes * Active treatment for a malignancy * Active wound in the knee * Recent history of knee trauma * Vasovagal history * An injection of hyaluronic acid (HA) or platelet-rich plasma (PRP) to the affected knee within the last two years. * In the judgment of the investigator, the patient is unable to perform and/or complete all of the study visits or treatments required.