Testing the Combination of Two Approved Chemotherapy Drugs and Radiation Prior to Surgery in Localized Pancreatic Cancer

Inclusion Criteria (all criteria must apply): * Cytologic or histologic proof of adenocarcinoma of the pancreas. * Localized, potentially resectable tumors. * Greater or equal to 18 years of age. * ECOG performance status of 0 or 1. * Adequate hematologic, renal and hepatic function as defined by: * ANC greater or equal to 1,500 cells/mm3 * Platelets greater or equal to 100,000 cells/mm3 * Serum bilirubin ≤ 1.5 x upper limit of normal (ULN) * Serum creatinine ≤ 2 x ULN • ALT ≤ 5 x ULN * AST ≤ 5 x ULN * No history of prior therapy for pancreatic cancer. * No history of active infection requiring IV antibiotics at the start of study treatment * Non-pregnant and non-breast-feeding. Exclusion Criteria: * Patient has borderline resectable or metastatic disease. * History of malignancy in the last 5 years other than in situ cancer or basal or squamous cell skin cancer or malignancies cured by surgery alone or surgery plus radiotherapy and have been continuously disease-free for at least 5 years. * Patient has active, uncontrolled bacterial, viral, or fungal infection(s) requiring systemic therapy.