No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
2 – 100
Sex
Any
Study type
Observational
Participants needed
1,000 (estimated)
Sponsor
National Heart, Lung, and Blood Institute (NHLBI) · NIH
Who this trial is looking for
This trial is looking for people aged 2 and older who may have genetic diseases affecting the heart and blood vessels, as well as their relatives and healthy volunteers. Participants will undergo various tests and evaluations to help researchers learn more about these conditions.
Are You a Good Fit for This Trial?
You may be able to join if
I am between the ages of 2 and 100 years old.
I may have a genetic disease affecting my heart or blood vessels.
I am a family member of someone affected.
I am a healthy volunteer.
You may not be able to join if
I am a healthy volunteer unable to give informed consent.
I am a healthy volunteer who does not want blood drawn or tissue studies.
I am cognitively impaired and not affected.
I am an unaffected unrelated pregnant woman.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
Background:
Some genetic diseases put increase the risk of heart and blood diseases, which are the number one cause of death and disability in the U.S. Researchers want to study diseases of the heart and/or blood vessels. They want to collect data and specimens from affected people, their family members, and healthy people.
Objective:
To study diseases of the heart and/or blood vessels.
Eligib…
Background:
Some genetic diseases put increase the risk of heart and blood diseases, which are the number one cause of death and disability in the U.S. Researchers want to study diseases of the heart and/or blood vessels. They want to collect data and specimens from affected people, their family members, and healthy people.
Objective:
To study diseases of the heart and/or blood vessels.
Eligibility:
People age 2 and older who may have genetic disease affecting the heart and/or blood vessels Their relatives
Healthy volunteers
Design:
Participants will be screened with a medical history, physical exams, and imaging tests. Participants may have a few visits or visits for 2 weeks or more. This will depend on their age and disease status. Visits may include:
Photographs of the face and body
Heart tests
Samples taken of blood, urine, saliva, skin, and/or tissue
Scans. For some, a dye may be injected into a vein.
A six-minute walk test
Lung tests. For some, participants will blow into a tube. For others, they will breathe in a gas from a mask, have a small injection, then have a scan.
Stress tests while walking on a treadmill or riding a stationary bike
Ultrasound of veins and arteries
Devices outside the body testing the stiffness and function of arteries
Eye exam and eye tests. For some, a dye may be injected in a vein.
Blood pressure tests
Measurements of blood flow under the skin and in the arms and fingernail blood vessels
Devices outside the body testing flexibility of the blood vessels and skin, and skin temperature
Trial Locations
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Status
Eligibility Criteria
* INCLUSION CRITERIA:
* All subjects must be between the ages of 2-100 years old.
* Affected pregnant women if they have been referred with a known or suspected pathology or if they become pregnant while on study.
* Unaffected related pregnant women (including spouses/partners) for cord blood and ti…
* INCLUSION CRITERIA:
* All subjects must be between the ages of 2-100 years old.
* Affected pregnant women if they have been referred with a known or suspected pathology or if they become pregnant while on study.
* Unaffected related pregnant women (including spouses/partners) for cord blood and tissue collection (surgical waste) only at the time of delivery.
EXCLUSION CRITERIA:
* Healthy volunteers unable to give informed consent
* Healthy volunteers who decline to have blood drawn and/or tissue studies or who do not consent to have samples stored for future research.
* Cognitively impaired individuals who are not affected.
* Cognitively impaired individuals not related to affected subjects.
* Unaffected unrelated pregnant women.
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