Post-Transplant Cyclophosphamide for Leukemia

Factors Affecting Post-transplant Cyclophosphamide (PTCy) Efficacy

Recruiting Observational Study
Leukemia, Not Otherwise Specified Leukemia, Other
No Placebo Group Every participant receives an active treatment — no one gets a placebo. No Study Drug Researchers observe your health over time — no experimental treatment is given.
Ready to participate?

Review the details below, then apply to join this clinical trial.

At a Glance
Age
18 and older
Sex
Any
Study type
Observational
Participants needed
120 (estimated)
Sponsor
Wake Forest University Health Sciences · Other
Who this trial is looking for

This trial is looking for adults who are receiving stem cell transplants for leukemia. Participants will have their treatment adjusted based on specific personal and genetic factors to improve outcomes and reduce side effects.

Are You a Good Fit for This Trial?

You may be able to join if

  • I am at least 18 years old.
  • I have given my consent to participate in the study.
  • I am scheduled to receive a stem cell transplant at Levine Cancer Institute.
  • I will receive post-transplant cyclophosphamide treatment.
  • I can understand and follow the study procedures.

You may not be able to join if

  • I do not have a willing donor for my transplant.
  • I have taken any investigational drug in the past 30 days.
  • My donor does not have a willing recipient for the transplant.

Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.

Think this trial could be right for you?

Answer a few quick questions to see if you may meet the eligibility requirements.

Check Your Eligibility
About This Trial

This study will examine the influence of donor and recipient pharmacogenetics (PG), drug pharmacokinetics (PK), and T cell phenotypes and how it may permit a tailored dosing strategy to improve the therapeutic index of post-transplant cyclophosphamide (PTCy) and optimize the graft versus tumor effect, while minimizing acute and chronic graft versus host disease (GVHD).

Trial Locations
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Eligibility Criteria
Inclusion Criteria Recipients and donors must meet all of the following applicable inclusion criteria to participate in this study: 1. Informed consent and HIPAA authorization for release of personal health information signed by the subject. 2. Age ≥ 18 years at the time of consent. 3. Subject is …
Contacts

Elizabeth Parke

980-442-2011

elizabeth.parke@atriumhealth.org

CONTACT