MRI Imaging for Heart and Other Organ Studies

* INCLUSION CRITERIA FOR HEALTHY VOLUNTEERS: * Age \>= 7 years * Able to follow instructions and lie still in the MRI scanner * Currently without known Cardiovascular disease * Able to provide informed consent in writing or provide guardian consent * Willingness to cooperate with all study procedures and available for scheduled study events EXCLUSION CRITERIA FOR HEALTHY VOLUNTEERS: * Important past or chronic medical illness such as major cardiovascular conditions like myocardial infarction, congenital heart disease, and known cardiomyopathy * Conditions that are thought to make MRI unsafe (that will be determined by filling out a separate form) including: * Cardiac pacemaker or implantable defibrillator unless it is labeled safe or conditional for MRI * Cerebral aneurysm clip unless it is labeled safe for MRI * Neural stimulator (e.g. TENS-Unit) unless it is labeled safe for MRI * Any type of ear or cochlear implant unless it is labeled safe for MRI * Ocular foreign body (e.g. metal shavings) * Metal shrapnel or bullet unless cleared by plain x-ray as safe for MRI * Any implanted device (e.g. insulin pump, drug infusion device), unless it is labeled safe or conditional for MRI * eGFR \< 60 mL/min/1.73m\^2 using the 2021 CKD-EPI equation or equivalent (using the CRIScalculated eGFR to define the threshold) and a serum creatinine measured within 2 weeks without intercurrent change in medical condition or medications. Subjects meeting this exclusion criterion may still be included in the study but may not be exposed to gadolinium-based contrast agents * Pregnancy. When uncertain of pregnancy status, subjects will undergo serum or urine pregnancy testing within the 7 days prior to the examination. Among those subjects who will receive MRI contrast, subjects of child-bearing potential will under serum or urine pregnancy testing within 7 days of the day prior to examination. In addition, the subject will be asked if she may be pregnant prior to the performance of the MRI, even if the pregnancy test was negative within the past week. The pregnancy test will be repeated if she answers in the affirmative. Post-menopausal and surgically sterilized subjects are automatically exempt from this testing. * If receiving contrast, breast feeding women (unless subject is willing to discard breast milk for 24 hours) are excluded * Healthy volunteer children will not have contrast * In a year's time, healthy volunteers are not restricted as to the number of non-contrast MRI examinations they undergo, but they may not undergo more than two examinations involving gadolinium-based contrast agents (GBCA) and those exposures will be at least 18 hours (12 half-lives) apart. INCLUSION CRITERIA FOR SUBJECTS WITH KNOWN OR SUSPECTED WITH HEART DISEASE: * Age \>= 7 years * Subjects with known or suspected cardiovascular disease * Able to provide informed consent in writing or provide guardian consent * Willingness to cooperate with all study procedures (including food restriction) and available for scheduled study events EXCLUSION CRITERIA FOR SUBJECTS WITH KNOWN OR SUSPECTED HEART DISEASE: * Conditions that are thought to make MRI unsafe (that will be determined by filling out a separate form) including: * Cardiac pacemaker or implantable defibrillator unless it is labeled safe or conditional for MRI * Cerebral aneurysm clip unless it is labeled safe for MRI * Neural stimulator (e.g. TENS-Unit) unless it is labeled safe for MRI * Any type of ear or cochlear implant unless it is labeled safe for MRI * Ocular foreign body (e.g. metal shavings) * Metal shrapnel or bullet unless cleared by plain x-ray as safe for MRI * Any implanted device (e.g. insulin pump, drug infusion device), unless it is labeled safe or conditional for MRI * Pregnancy. When uncertain of pregnancy status, subjects will undergo serum or urine pregnancy testing within the 7 days prior to the examination. Among those subjects who will receive MRI contrast, subjects of child-bearing potential will undergo serum or urine pregnancy testing 7 days prior to examination. In addition, the subject will be asked if she may be pregnant prior to the performance of the MRI, even if the pregnancy test was negative within the past week. The pregnancy test will be repeated if she answers in the affirmative. Post-menopausal and surgically sterilized subjects are automatically exempt from this testing. * Breast feeding (unless subject is willing to discard breast milk for 24 hours if receiving contrast) * eGFR \< 30 mL/min/1.73m\^2 using the 2021 CKD-EPI equation or Community Practice Standard for Pediatric case or equivalent and a serum creatinine measured within 2 weeks without intercurrent change in medical condition or medications. Subjects meeting this exclusion criterion may still be included in the study but may not be exposed to gadolinium-based contrast agents * Cardiorespiratory instability as determined by the enrolling clinician INCLUSION CRITERIA FOR SUBJECTS WITH NON-CARDIAC DISEASE: * Age \>= 7 years * Able to provide informed consent in writing or provide guardian consent * Willingness to cooperate with all study procedures (including food restriction) and available for scheduled study events * Known or suspected brain, hematology, oncology, endocrine, pulmonary, or other non-cardiac disease. EXCLUSION CRITERIA FOR SUBJECTS WITH NON- CARDIAC DISEASE: * Conditions that are thought to make MRI unsafe (that will be determined by filling out a separate screening form) including: * Cardiac pacemaker or implantable defibrillator unless it is labeled safe or conditional for MRI * Cerebral aneurysm clip unless it is labeled safe for MRI * Neural stimulator (e.g. TENS-Unit) unless it is labeled safe for MRI * Any type of ear or cochlear implant unless it is labeled safe for MRI * Ocular foreign body (e.g. metal shavings) * Metal shrapnel or bullet unless cleared by plain x-ray as safe for MRI * Any implanted device (e.g. insulin pump, drug infusion device), unless it is labeled safe or conditional for MRI * Pregnancy. When uncertain of pregnancy status, subjects will undergo serum or urine pregnancy testing within the 7 days prior to the examination. Among those subjects who will receive MRI contrast, subjects of child-bearing potential will undergo serum or urine pregnancy testing on the day of the examination. In addition, the subject will be asked if she may be pregnant prior to the performance of the MRI, even if the pregnancy test was negative within the past week. The pregnancy test will be repeated if she answers in the affirmative. Post-menopausal and surgically sterilized subjects are automatically exempt from this testing. * Breast feeding in those subjects receiving contrast (unless subject is willing to discard breast milk for 24 hours * eGFR \< 30 mL/min/1.73m\^2 using the 2021 CKD-EPI equation or equivalent and a serum creatinine measured within 2 weeks without intercurrent change in medical condition or medications. Subjects meeting this exclusion criterion may still be included in the study but may not be exposed to gadolinium-based contrast agents * Cardiorespiratory instability or as determined by the enrolling clinician