Diesel Exhaust Induces Glucocorticoid Resistance
Recruiting
Phase 4
Interventional Study
Exposure to Pollution
Glucocorticoid Resistance
Prior Safety Data
This treatment has already been tested in at least one earlier human trial.
At a Glance
- Age
- 19 – 49
- Sex
- Any
- Trial phase
- Phase 4
- Study type
- Interventional
- Purpose
- Prevention
- Participants needed
- 30 (estimated)
- Sponsor
- University of British Columbia · Other
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About This Trial
The investigators are studying the effects of exposure to diesel exhaust on lung inflammation in the presence and absence of an inhaled corticosteroid. Although data is mixed, studies show that asthmatics have increased lung inflammation and worse symptoms during periods of higher air pollution despite taking their anti-inflammatory corticosteroid medication. One possible reason is that air pollut…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
1. Aged 19-49
2. Have physician-diagnosed asthma confirmed by the study physician examination, spirometry, methacholine challenge provocative concentration causing a 20% fall (PC20) of \<16 mg/mL, and questionnaires during a screening visit
Exclusion Criteria:
1. Smoking of an…
Contacts