Janus Kinase Inhibition to Prevent Ventilator-induced Diaphragm Dysfunction
Recruiting
Phase 2
Interventional Study
Diaphragm Injury
Prior Safety Data
This treatment has already been tested in at least one earlier human trial.
At a Glance
- Age
- 18 and older
- Sex
- Any
- Trial phase
- Phase 2
- Study type
- Interventional
- Purpose
- Prevention
- Participants needed
- 70 (estimated)
- Sponsor
- Stanford University · Other
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About This Trial
We intend, with this study, to prove that blocking the molecular mechanisms whose blockade prevents VIDD in animals, will indeed prevent the development of VIDD in humans as well. We believe that this evidence will serve as the required basis for proceeding with large, ICU-based clinical trial(s) of a drug to prevent VIDD.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Patients undergoing esophagectomy
Exclusion Criteria:
* Patients with more than mild pulmonary dysfunction
* Patients with any neuromuscular disease that might compromise diaphragm function
* Patients with abnormal liver or kidney function
* Patients taking any immunosuppres…
Contacts