IMA203/IMA203CD8 for Recurrent Solid Tumors

ACTengine® IMA203/IMA203CD8 as Monotherapy or in Combination With Nivolumab in Recurrent and/or Refractory Solid Tumors

Recruiting Phase 1 Phase 2 Interventional Study
Refractory Cancer Recurrent Cancer Solid Tumor, Adult Cancer
No Placebo Group Every participant receives an active treatment — no one gets a placebo. Prior Safety Data This treatment has already been tested in at least one earlier human trial.
Ready to participate?

Review the details below, then apply to join this clinical trial.

At a Glance
Age
18 and older
Sex
Any
Trial phase
Phase 1/2
Study type
Interventional
Purpose
Treatment
Participants needed
375 (estimated)
Sponsor
Immatics US, Inc. · Industry
Who this trial is looking for

This trial is looking for patients with certain types of cancer that keep coming back or do not respond to standard treatments. Participants will receive the study treatment IMA203/IMA203CD8, either alone or with nivolumab.

Are You a Good Fit for This Trial?

You may be able to join if

  • I have recurrent or progressing solid tumors.
  • I have measurable disease.
  • I have recovered from any side effects of previous therapy.
  • I have an HLA-A*02:01 positive test.
  • My life expectancy is more than 5 months.
  • I am a female of childbearing potential using contraception.
  • I am a male agreeing to use effective contraception.

You may not be able to join if

  • I am pregnant or breastfeeding.
  • I have a serious autoimmune disease.
  • I have a history of cardiac conditions.
  • I have HIV or active hepatitis B or C.
  • I have had a stem cell or solid organ transplantation.
  • I have active brain metastases.
  • I have had severe reactions to PD1/PD-L1 inhibitor therapy.
  • I have a significant medical disease that could affect the study.

Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.

Think this trial could be right for you?

Answer a few quick questions to see if you may meet the eligibility requirements.

Check Your Eligibility
About This Trial

The study's purpose is to establish the safety and tolerability of IMA203/IMA203CD8 products with or without combination with nivolumab in patients with solid tumors that express preferentially expressed antigen in melanoma (PRAME).

Trial Locations
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Eligibility Criteria
Inclusion Criteria: * Patients must have recurrent/progressing and/or refractory solid tumors and must have received or not be eligible for all available indicated standard of care treatment. * Eastern Cooperative Oncology Group (ECOG) performance status 0-1 * HLA-A\*02:01 positive * For patients w…
Contacts

Immatics US, Inc.

+1 346 204-5400

ctgovinquiries@immatics.com

CONTACT