High-Frequency Oscillation Ventilation Versus Conventional Mechanical Ventilation in Very Preterm Infants With Perinatal Acute Respiratory Distress Syndrome: Multicenters Randomized Controlled, Superiority Trial
Recruiting
N/A
Interventional Study
Acute Respiratory Distress Syndrome
High Frequency Oscillatory Ventilation
Preterm
Conventional Mechanical Ventilation
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
At a Glance
- Age
- 1 Minute – 1 Hour
- Sex
- Any
- Study type
- Interventional
- Purpose
- Treatment
- Participants needed
- 400 (estimated)
- Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University · Other
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About This Trial
Bronchopulmonary dysplasia (BPD) is a complex disorder and remains the most common complication in very preterm infants. Its incidence is increased with gestational age from 95.5% among infants born at 22 weeks' gestation to 22.2% among those born at 29 weeks' gestation. BPD is associated with the increased risks of delayed neurodevelopment and pulmonary impairment. High incidences of BPD and morb…
Trial Locations
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Eligibility Criteria
Inclusion criteria
1. GA was between 24+0 and 31+6 weeks.
2. Preterm neonates were admitted to NICU within 1 hours after birth, diagnosed with perinatal ARDS using Montreux guidelines and stable supported by CMV.
3. Stabilization for 2 hours before randomization: FiO2 0.40, mean airway pressure (MA…
Contacts
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