Ferritin and Iron Burden in SAH sIRB

Recruiting Phase 1 Phase 2 Interventional Study
SAH Dementia
Prior Safety Data This treatment has already been tested in at least one earlier human trial.
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At a Glance
Age
18 – 75
Sex
Any
Trial phase
Phase 1/2
Study type
Interventional
Purpose
Treatment
Participants needed
66 (estimated)
Sponsor
Duke University · Other
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About This Trial
Ruptured cerebral aneurysms lead to subarachnoid hemorrhage (SAH),that has a high morbidity and mortality rate, the severity of which is predicted by the "Hunt-Hess grade" (HHG). SAH leads to iron (Fe) and hemoglobin (Hb) accumulation in the brain, which is toxic for neurons. Ferritin (iron reported in the brian) and iron overload leads to brain atrophy, specifically in the mesial temporal lobe (…
Trial Locations
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Eligibility Criteria
Inclusion criteria: 1. Age greater than or equal to 18 and less than or equal to 75 years. 2. Historical modified Rankin Scale Score (mRS) 0-1 (pre-subarachnoid hemorrhage onset). 3. World Federation of Neurosurgical Societies SAH Scale (WFNS) grade less than or equal to 4, due to a spontaneous SAH…
Contacts

David Hasan, MD

919-681-2512

david.hasan@duke.edu

CONTACT

Beth Perry, RN

919-681-2695

beth.perry@duke.edu

CONTACT