Neuroinflammation Assessment in Chronic Pain and Fatigue
Assessment of Neuroinflammation in Central Inflammatory Disorders Using [F-18]DPA-714.
Recruiting
Phase 1
Interventional Study
Fibromyalgia
Chronic Fatigue Syndrome
Multiple Sclerosis
Healthy
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
At a Glance
- Age
- 18 – 65
- Sex
- Any
- Trial phase
- Phase 1
- Study type
- Interventional
- Purpose
- Diagnostic
- Participants needed
- 120 (estimated)
- Sponsor
- University of Alabama at Birmingham · Other
Who this trial is looking for
This trial is looking for individuals aged 18 to 65, with chronic pain or fatigue, or healthy volunteers. Participants will undergo brain imaging to measure neuroinflammation levels.
Are You a Good Fit for This Trial?
You may be able to join if
- I am between 18 and 65 years old.
- I have a clinical diagnosis of Multiple Sclerosis.
- I meet the criteria for fibromyalgia.
- I meet the criteria for Chronic Fatigue Syndrome.
- I am a healthy volunteer.
You may not be able to join if
- I cannot have an MRI.
- I am pregnant.
- I am breastfeeding.
- I have a severe medical condition that prevents participation.
- I have a chronic infectious disease.
- I have had a viral or bacterial illness that needed treatment in the last month.
- I have been diagnosed with cancer.
- I have a blood or blood clotting disorder.
Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
Check Your Eligibility
About This Trial
The primary objective of this study is to measure the concentration and the regional brain distribution of activated brain microglia/macrophages using the PET radiopharmaceutical \[F-18\]DPA-714 in individuals with chronic pain and fatigue suspected to be associated with neuroinflammation. The PET tracer \[F-18\]DPA-714 binds to the 18 kDa translocator protein (TSPO, also known as the peripheral b…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
1. 18 to 65 years of age
2. Healthy volunteer OR Clinical diagnosis of Multiple Sclerosis (MS) OR Meets 2016 American College of Rheumatology (ACR) case definition criteria for fibromyalgia OR Meets 1994 Fukuda case definition criteria for Chronic Fatigue Syndrome
Exclusion Cri…
Contacts