MRI-targeted Biopsy of the Prostate: Software Versus Visual Registration in the Accuracy of Prostate Cancer Detection

Inclusion Criteria: * willing to participate in the study by giving written informed consent. * male subjects aged between 50 to 75 years. * with a clinical suspicion of PCa: elevated prostate specific antigen (PSA) levels in blood and/or abnormal digital rectal examination (DRE). * good health condition based on medical history, physical examination and vital sign measurements. * with target lesion on dedicated MRI of the prostate (PI-RADS 3 to 5). Exclusion Criteria: * has a prior history of prostate cancer. * had prior prostate biopsy. * has a contra-indication for MRI (claustrophobia, non-compatible metallic implants). * has evidence of lymph nodes involvement on prostate MRI or abdominal CT * has evidence of bone metastasis on bone scan. * has a prior history of hip prosthesis, pelvic radiation therapy or androgen deprivation therapy * unable to perform transrectal ultrasound due to prior rectal surgery or active rectal diseases (rectitis, …) * has any condition, physical, mental, familial or sociological, that could impede compliance with the study protocol and further follow-up. This is not an absolute contra-indication, but should be discussed with patient prior to registration in the trial.