Neoadjuvant FOLFIRINOX in the Treatment of Locally Advanced Gastric Cancer

Inclusion Criteria: * Histological diagnosis of gastric adenocarcinoma that is amenable to surgical resection at diagnosis, with locally advanced disease criteria for clinical evaluation (T3 tumors, T4 tumors and / or regional lymph node involvement). * Absence of metastatic disease at a distance (computerized tomography, diagnostic laparoscopy and peritoneal lavage). * Age 18-75 years. * Clinical functionality by the ECOG scale between 0 and 1. * Preserved renal function (creatinine clearance greater than 50 mL / min). * Signature of Informed Consent Form Exclusion Criteria: * Active neoplasm of another primary site other than non-melanoma skin carcinoma. * Lesions of the esophagogastric transition * Unresectable lesions by computed tomography and / or diagnostic laparoscopy. * Obstructive tumors (acute intestinal occlusion or subocclusion). * Tumors with signs of significant or persistent bleeding. * Carcinoma in situ. * Different histological type of adenocarcinoma. * Gastric stump tumors. * Previous chemotherapeutic or radiotherapy treatment. * Current pregnancy or breastfeeding. * Total bilirubin above 1.5mg / dL. * Hepatic transaminases greater than 1.5 times the upper limit of normality. * Decompensated and / or symptomatic cardiomyopathy: congestive heart failure with functional class greater than 2 by the New York Heart Association; active coronary disease; uncontrolled cardiac arrhythmia; history of acute myocardial infarction in the last 6 months. * Psychological, familial, social or even geographical condition that potentially hinders adherence to the study protocol and the pre-established follow-up. * Current or previous psychiatric or neurological diagnosis that is decompensated, compromises the cognition, functionality or adherence to the proposed treatment. * Other comorbidities that are decompensated at the time of treatment. * Pregnant or breastfeeding women.