Epinephrine Dose: Optimal Versus Standard Evaluation Trial
Recruiting
Phase 4
Interventional Study
Cardiac Arrest, Out-Of-Hospital
Sudden Cardiac Arrest
Ventricular Fibrillation
Ventricular Tachycardia-Pulseless
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Prior Safety Data
This treatment has already been tested in at least one earlier human trial.
At a Glance
- Age
- 18 and older
- Sex
- Any
- Trial phase
- Phase 4
- Study type
- Interventional
- Purpose
- Treatment
- Participants needed
- 3,790 (estimated)
- Sponsor
- Unity Health Toronto · Other
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About This Trial
The objective of this randomized controlled trial is to evaluate the effectiveness of a low cumulative dose of epinephrine compared to a standard cumulative dose of epinephrine during resuscitation from ventricular fibrillation (VF) or ventricular tachycardia (VT) in adult out-of-hospital cardiac arrest (OHCA) patients.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Out-of-hospital cardiac arrest treated by paramedics
* Initial recorded cardiac rhythm of VF or pulseless VT, or, AED shock on first analysis administered or witnessed by EMS (paramedic or fire)
* Established intravenous vascular access
Exclusion Criteria:
* Known or apparen…
Contacts