Long Term Follow-Up of Patients With Mesothelioma and Individuals With Germline Mutations in BAP1

* Inclusion Criteria for Genetic Testing: Cohort 1: * Participant with pathology confirming a diagnosis of mesothelioma. * Participant must have a deleterious germline BAP1 mutation. Results from either research or clinical analyses are sufficient for this criterion. OR * Participant with mesothelioma otherwise eligible for genetic testing in Cohort 2 * Age \>= 2 years Cohort 2: -Individual with a germline BAP1 mutation who does not have a history of mesothelioma (other cancers are allowed). Results from either research or clinical analyses are sufficient for this criterion. OR -Individual with no history of mesothelioma with: --A biological first degree relative (living or deceased) with a history of mesothelioma OR --A first degree biological relative with a CLIA (or equivalent) confirmed germline mutation in BAP1 OR --A second degree biological relative with a CLIA (or equivalent) confirmed germline mutation in BAP1 if relevant first degree relative is deceased or unavailable for testing, OR --A second degree biological relative with mesothelioma and a CLIA (or equivalent) confirmed germline mutation in BAP1 -Age \>= 2 years All participants must understand and be willing to sign a written informed consent Exclusion Criteria for Genetic Testing None Inclusion Criteria for Surveillance: Inclusion Criteria for Surveillance * Genetic testing criteria including age restrictions for respective cohorts must be met. * Participants in Cohort 1 may be enrolled with positive results for germline BAP1 mutation regardless of CLIA (or equivalent) confirmation * Participants in Cohort 2: * must have CLIA (or equivalent) confirmed germline BAP1 mutation Exclusion Criteria for Surveillance None