Rumination-Focused Treatment for Adolescent Depression

Mechanisms of Rumination Change in Adolescent Depression

Recruiting N/A Interventional Study
Major Depressive Disorder Mood Disorders
No Placebo Group Every participant receives an active treatment — no one gets a placebo.
Ready to participate?

Review the details below, then apply to join this clinical trial.

At a Glance
Age
14 – 17
Sex
Any
Study type
Interventional
Purpose
Prevention
Participants needed
183 (estimated)
Sponsor
Ohio State University · Other
Who this trial is looking for

This trial is looking for teenagers aged 14-17 with a history of depression. Participants will receive a new type of therapy that helps change negative thinking patterns, aiming to reduce the chances of depression returning.

Are You a Good Fit for This Trial?

You may be able to join if

  • I have been diagnosed with Major Depressive Disorder.
  • I am 14-17 years old.
  • I have a score above the average for rumination.
  • I have full or partial remission from depression for at least two weeks.
  • I am postpubertal.
  • I have an IQ above 75.
  • I give my assent to participate and my parent gives consent.

You may not be able to join if

  • I have thoughts of suicide with a plan or intent.
  • I have a history of conduct disorder, autism, psychotic disorders, or bipolar disorder.
  • I have had an eating disorder or substance abuse in the past 6 months.
  • I have been treated with the same type of therapy as this study in the last 2 years.
  • I have metal braces, tattoos with metal, or clothing with metal fibers.
  • I have claustrophobia.
  • I am currently pregnant.
  • I take medications other than antidepressants.

Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.

Think this trial could be right for you?

Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.

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About This Trial
This study will evaluate whether a newer treatment, rumination-focused cognitive behavioral treatment, which includes mindfulness and can be used to reduce ruminative habits, change ways in which key brain regions interact with each other (e.g.., often called connectivity), and whether these changes in habits and brain connectivity can reduce the risk for recurrence of depression in the next two y…
Trial Locations
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Eligibility Criteria
Inclusion Criteria: * Previous diagnosis of Major Depressive Disorder (full or partial remission for at least two weeks) according to Diagnostic and Statistical Manual (DSM-V) criteria confirmed by the Kiddie Schedule for affective disorders (KSADSPL). Partial remission is defined as not meeting fu…
Contacts

Scott A Langenecker, Ph.D.

734-276-3889

scott.langenecker@osumc.edu

CONTACT

Caty Escobar, M.S.

301-648-3426

caty.escobar@osumc.edu

CONTACT