No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
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Review the details below, then apply to join this clinical trial.
At a Glance
Age
14 – 17
Sex
Any
Study type
Interventional
Purpose
Prevention
Participants needed
183 (estimated)
Sponsor
Ohio State University · Other
Who this trial is looking for
This trial is looking for teenagers aged 14-17 with a history of depression. Participants will receive a new type of therapy that helps change negative thinking patterns, aiming to reduce the chances of depression returning.
Are You a Good Fit for This Trial?
You may be able to join if
I have been diagnosed with Major Depressive Disorder.
I am 14-17 years old.
I have a score above the average for rumination.
I have full or partial remission from depression for at least two weeks.
I am postpubertal.
I have an IQ above 75.
I give my assent to participate and my parent gives consent.
You may not be able to join if
I have thoughts of suicide with a plan or intent.
I have a history of conduct disorder, autism, psychotic disorders, or bipolar disorder.
I have had an eating disorder or substance abuse in the past 6 months.
I have been treated with the same type of therapy as this study in the last 2 years.
I have metal braces, tattoos with metal, or clothing with metal fibers.
I have claustrophobia.
I am currently pregnant.
I take medications other than antidepressants.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
This study will evaluate whether a newer treatment, rumination-focused cognitive behavioral treatment, which includes mindfulness and can be used to reduce ruminative habits, change ways in which key brain regions interact with each other (e.g.., often called connectivity), and whether these changes in habits and brain connectivity can reduce the risk for recurrence of depression in the next two y…
This study will evaluate whether a newer treatment, rumination-focused cognitive behavioral treatment, which includes mindfulness and can be used to reduce ruminative habits, change ways in which key brain regions interact with each other (e.g.., often called connectivity), and whether these changes in habits and brain connectivity can reduce the risk for recurrence of depression in the next two years.
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Eligibility Criteria
Inclusion Criteria:
* Previous diagnosis of Major Depressive Disorder (full or partial remission for at least two weeks) according to Diagnostic and Statistical Manual (DSM-V) criteria confirmed by the Kiddie Schedule for affective disorders (KSADSPL). Partial remission is defined as not meeting fu…
Inclusion Criteria:
* Previous diagnosis of Major Depressive Disorder (full or partial remission for at least two weeks) according to Diagnostic and Statistical Manual (DSM-V) criteria confirmed by the Kiddie Schedule for affective disorders (KSADSPL). Partial remission is defined as not meeting full DSM-V criteria for MDD.
* RRS score above the age and sex specific mean, T \> 50).
* 14-17 years of age at enrollment (accounting for 2 year follow-up),
* Postpubertal (Petersen Pubertal Developmental Scale)
* Youth assent and parent consent
* Intellectual Quotient (IQ) \> 75, determined by Wechsler Abbreviated Scale of Intelligence (WASI)
Exclusion Criteria:
* Endorsement of suicidality with plan or intent (assessed via KSADSPL and Children's Depression Rating Scale (CDRS-R) clinical interviews. Current or past (within previous three months) plan or intent is exclusionary.
* Lifetime history of conduct disorder, autism, any psychotic disorder (or episode unexplained by other known medical causes), or bipolar disorder. Eating disorder or alcohol/substance abuse within the previous 6 months. (Lifetime history of an anxiety disorder, disruptive mood dysregulation disorder or oppositional defiant disorder, Attention Deficit Hyperactivity Disorder (ADHD) will not be exclusionary).
* Current treatment with RF-CBT, Cognitive Behavioral Therapy (CBT), or variants thereof, or in the last 2 years. Likewise, detail oriented therapy beyond supportive therapy (e.g., homework, cognitive restructuring), in same time window (ability to recall elements of structured therapies with CBT focus).
* Metal braces or retainers, tattoos with metal, or clothing with metal fibers.
* Claustrophobia
* Current pregnancy - Parents will be asked this information at the phone screen. At the clinic eligibility visit, female participants will be asked about sexual activity in a private room separate from their parents using the pregnancy script/screen that the investigators have created. This script details that if a female is ineligible due to pregnancy or inadequate birth control, this information will not be disclosed to her parent(s). Participants who are sexually active will be asked about birth control method. Abstinence will be considered an approved form of contraception.
* Psychotropic medication outside of antidepressants such as mood stabilizers and antipsychotics will be exclusionary. Participants may have a history of current, stable antidepressant medication use, with no changes in dose for the past four weeks, no change in specific medication for six weeks.
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