OH2 Oncolytic Viral Therapy in Solid Tumors

Inclusion Criteria: 1. Histologically or cytologically confirmed unresectable or recurrent/metastatic solid tumors. 2. The patient must have failed the standard treatment (due to either disease progression or intolerable toxicity) or the standard of care had not been established for the specific condition. 3. Measurable disease based on Response Evaluation Criteria In Solid Tumors (RECIST) 1.1. 4. Eastern Collaborative Oncology Group (ECOG) Performance Status ≤ 1. 5. Life expectancy \>3 months. 6. The patient must have at least one tumor site appropriate for intratumoral injection. 7. Adequate organ function. 8. Participants of reproductive potential must be willing to use adequate contraception for the course of the study until 3 months after the last dose of any of the drugs in the study. 9. Participants with a history of HSV infection must have recovered at least 3 months before the study. 10. Willing and able to provide written informed consent and comply with the requirements of the study. Exclusion Criteria: 1. Uncontrolled concurrent illness including, but not limited to, severe cardiac disease, cerebralvascular disease, uncontrolled diabetes, uncontrolled hypertension, ongoing or active systemic infection, active peptic ulcer disease. 2. Central nervous system (CNS) metastases with clinical symptoms 3. Active infection or an unexplained fever \> 38.5°C. 4. Known Human Immunodeficiency Virus (HIV) infection, active Hepatitis B or Hepatitis C infection. 5. Pregnant or lactating female. 6. Patients who are receiving any other investigational agents. 7. Known immediate or delayed hypersensitivity reaction to HSV. 8. Previous malignancy within 5 years prior to study entry. 9. Patients with any active autoimmune disease or history of autoimmune disease. 10. Concurrent medical condition requiring the use of cortisol (\>10mg/day prednisone or equivalent dose) or other systematic immunosuppressive medications within 14 days before the study treatment, except for inhalation or topical corticosteroids no more than 10 mg/day prednisone or equivalent. 11. Familial, sociological or geographical conditions that, in the judgment of the investigator, do not permit compliance with the protocol.