Nutrition and Exercise for Advanced Prostate Cancer Survivors
Nutrition and Exercise Interventions for Androgen Deprivation Therapy-Induced Obese Frailty in Elderly and Non-Elderly Survivors of Advanced Prostate Cancer
Recruiting
N/AInterventional Study
Cancer SurvivorObesityOverweightProstate AdenocarcinomaStage A Prostate CancerStage B Prostate CancerStage C Prostate CancerStage D Prostate CancerStage I Prostate CancerStage II Prostate CancerStage IIA Prostate CancerStage IIB Prostate CancerStage IIC Prostate CancerStage III Prostate CancerStage IIIA Prostate CancerStage IIIB Prostate CancerStage IIIC Prostate CancerStage IV Prostate CancerStage IVA Prostate CancerStage IVB Prostate Cancer
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
18 and older
Sex
Male
Study type
Interventional
Purpose
Supportive Care
Participants needed
50 (estimated)
Sponsor
Roswell Park Cancer Institute · Other
Who this trial is looking for
This trial is looking for prostate cancer survivors who have been on hormone therapy for less than 5 years. Participants will receive personalized nutrition and exercise advice to help reduce weight-related frailty.
Are You a Good Fit for This Trial?
You may be able to join if
I have been diagnosed with prostate cancer.
I have been on hormone therapy for less than 5 years.
My hemoglobin level is above 11 g/dL.
My kidney and liver function tests are within normal limits.
I can walk at least 100 meters without help.
I can read, write, and understand English.
I can give consent to participate in the study.
You may not be able to join if
I have severe chronic lung disease.
I have heart disease or heart failure.
I have serious joint or muscle problems.
I am too frail overall to participate.
I cannot have extra blood drawn for the study.
I am unwilling or unable to follow the study rules.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
This trial studies how well nutrition and exercise interventions work in reducing androgen deprivation therapy-induced obese frailty in prostate cancer survivors. Individualized nutrition and exercise advice for prostate cancer patients on androgen deprivation therapy may help to reduce obese frailty and change the levels of myokines in blood.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Biopsy-confirmed prostate adenocarcinoma of any stage/grade
* Prescribed or already receiving continuous ADT for \< 5 years
* Hemoglobin \> 11 g/dL
* Creatinine \< 1.5 x upper limit of normal (ULN), AST or ALT \<2 x ULN within 6 months prior to enrollment
* Liver function test…
Inclusion Criteria:
* Biopsy-confirmed prostate adenocarcinoma of any stage/grade
* Prescribed or already receiving continuous ADT for \< 5 years
* Hemoglobin \> 11 g/dL
* Creatinine \< 1.5 x upper limit of normal (ULN), AST or ALT \<2 x ULN within 6 months prior to enrollment
* Liver function tests \< 2 x ULN
* Able to walk unassisted at least 100 meters (200 steps) or ECOG \<= 1
* No contraindications to any aspect of participation, including aerobic exercise
* Participant must be able to read, write, and understand the English language and be able to provide written consent
* Participant must understand the investigational nature of this study and sign an Independent Ethics Committee/Institutional Review Board approved written informed consent form prior to receiving any study related procedure
Exclusion Criteria:
* Known clinically significant severe chronic obstructive pulmonary disease (COPD), ischemic heart disease, congestive heart failure, and/or significant cardiac arrhythmias
* Limiting orthopedic, musculoskeletal or psychological conditions (clinician discretion)
* Overall medical frailty (clinician discretion)
* Any condition contraindicating additional blood collection beyond standard of care
* Unwilling or unable to follow protocol requirements
* Any condition which in the investigator's opinion deems the participant an unsuitable candidate to receive study intervention
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